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November 30, 2025Advanced ScienceOpen Access

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes

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Authors

XXXiao XuQHQiqing HuangYLYang Liu

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Overview

This approach demonstrates enhanced energy disruption in tumors using targeted mitochondrial interference, suggesting improved cancer treatment strategies.

Key Points

  • Energy disruption in tumors through targeted mitochondrial and lysosomal damage is achieved.
  • The approach effectively combines mitochondrial dysfunction and lysosomal alkalinization.
  • This mechanism, involving biomimetic nanoparticles, suggests a novel therapeutic avenue for drug-resistant cancer.
  • Enhancing precision therapy may potentiate treatment effectiveness against established drug resistance.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/692b94341d383f2b2a378732https://doi.org/10.1002/advs.202517373
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes2025
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  3. 3Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges2026
  4. 4Strategic disruption of cancer’s powerhouse: precise nanomedicine targeting of mitochondrial metabolism2024 · 12 citations
  5. 5Mitochondria‐Targeted Nanomotor: H <sub>2</sub> S‐Driven Cascade Therapy for Hepatocellular Carcinoma2025