December 2, 2025Frontiers in ImmunologyOpen Access

Comparative pathophysiology and molecular insights into cutaneous and non-cutaneous canine skin cancers: focus on melanoma, mast cell tumors, and squamous cell carcinoma

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Comparative analysis reveals pathophysiology variations in canine skin cancers, suggesting new therapeutic targets.

Melanoma treatment showed emerging therapies improve outcomes in canine oncology, with significant implications for skin cancer.
Squamous cell carcinoma demonstrates strong association with UV radiation exposure, leading to carcinogenic mutations such as TP53 and COX-2.
Assessment using advanced imaging techniques enhances diagnosis accuracy and may aid in therapeutic decisions for skin cancers.
Pathophysiological insights emphasize the role of mutations, such as in the KIT proto-oncogene, in the development of canine neoplasms.

Sorin Marian Mârza (2025) studied this question.

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