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This review examines the potential of natural compounds as treatments for cutaneous squamous cell carcinoma (SCC) in veterinary medicine.

June 17, 2026Open Access

Natural Compounds for the Treatment of Cutaneous Squamous Cell Carcinoma: A Systematic Review of Preclinical and Clinical Evidence

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Systematic review consolidates preclinical and clinical evidence of natural compounds for SCC, suggesting novel therapies.

This review examines the potential of natural compounds as treatments for cutaneous squamous cell carcinoma (SCC) in veterinary medicine.
Conducted a systematic review of both preclinical and clinical studies on natural compounds for SCC treatment.
Focused on compounds exhibiting anti-cancer properties through various biological pathways such as apoptosis and angiogenesis.
Reviewed literature to synthesize data on the efficacy and mechanisms of plant-derived compounds against SCC.
Natural compounds like curcumin and resveratrol showed significant anticancer effects through multiple mechanisms.
Evidence suggests lower toxicity and favorable profiles compared to conventional treatments like chemotherapy and radiation.
Highlighted the need for further studies to explore the therapeutic potential of these compounds in veterinary oncology.

Forno-Bell et al. (2026) studied this question.

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