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This review evaluates the effectiveness of natural compounds in treating cutaneous squamous cell carcinoma (cSCC).

Natural Compounds for the Treatment of Cutaneous Squamous Cell Carcinoma: A Systematic Review

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Systematic review evaluates antitumoral activity of natural compounds against cutaneous SCC, indicating their potential benefits.

This review evaluates the effectiveness of natural compounds in treating cutaneous squamous cell carcinoma (cSCC).
Conducted a systematic literature search adhering to PRISMA 2020 guidelines.
Analyzed sixty studies focusing on various formulations, including purified compounds, essential oils, and photodynamic agents.
Used a mechanism-based classification framework to assess antitumoral activity.
Natural compounds demonstrated antitumoral activity through mechanisms like apoptosis and redox modulation.
Purified compounds exhibited higher mechanistic specificity than complex extracts.
Several agents showed consistent in vitro and in vivo activity, supporting potential clinical applications.

Forno-Bell et al. (2026) studied this question.

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