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December 4, 2025Netherlands Heart JournalOpen Access

The impact of aging on acute coronary syndromes: an EHR-based analysis

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Authors

CSCharlotte E. P. SiegersJRJan van Ramshorst

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Overview

Observational analysis found higher mortality rates in older age groups and highlights optimal medical treatment versus invasive strategy in ACS patients.

Key Points

  • Mortality rates increased with age; 15% in nonagenarians at 30 days, suggesting a need for tailored interventions.
  • Analysis included 1,036 ACS patients aged 80+, comparing invasive strategy to optimal medical treatment outcomes.
  • Method involved multi-variation analyses across three age groups: 80–84, 85–89, and 90+ with focus on patient characteristics.
  • Study supports appropriate selection of invasive strategies in octo- and nonagenarians for better safety and outcomes.

Cite This Study

Siegers et al. (2025) studied this question.

synapsesocial.com/papers/6930dc9eea1aef094cca2cd7https://doi.org/10.1007/s12471-025-02003-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of an invasive strategy in the elderly hospitalized with acute coronary syndrome with emphasis on the nonagenarians2018 · 7 citations
  2. 2Temporal trends in the treatment and outcome of nonagenarians with acute coronary syndrome2024
  3. 3In-hospital Outcome in Octogenarians with Acute Coronary Syndrome Undergoing Emergent Coronary Angiography.2003 · 5 citations
  4. 4The impact of increased age on outcome from a strategy of early invasive management and revascularisation in patients with acute coronary syndromes: retrospective analysis study from the ACACIA registry2012 · 84 citations
  5. 5Acute coronary syndrome in octogenarian patients: results from the international registry of acute coronary syndromes in transitional countries (ISACS-TC) registry2014 · 19 citations