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January 1, 2014European Heart Journal SupplementsOpen Access

Acute coronary syndrome in octogenarian patients: results from the international registry of acute coronary syndromes in transitional countries (ISACS-TC) registry

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Key result

In octogenarians with acute coronary syndrome, in-hospital mortality was similar between women (21.1%) and men (21.0%), with hypotension, Killip class ≥2, and STEMI as independent predictors of death.

Population

437 patients ≥ 80 years old, consecutively admitted with a diagnosis of acute coronary syndrome, mean age…

Design

Cohort

Follow-up

in-hospital

Authors

OMOlivia ManfriniMDMaria DorobanţuZVZorica Vasiljević

Discussion

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Overview

Alerts clinicians to high-risk octogenarian ACS in transitional countries; leaves open targeted strategies pending prospective trials.

Study Design

Type

Cohort (n=437)

Multicenter

Yes

Structured PICO

P
Population
437 patients aged ≥ 80 years admitted with acute coronary syndrome across 14 hospitals in 8 Eastern European countries, evaluated for in-hospital mortality.
O
Outcome
In-hospital mortalityhard clinical

Main Result

Absolute Event Rate: 21.1% vs 21%

In octogenarians with ACS, clinical factors like hypotension, higher Killip class, and STEMI are strong predictors of in-hospital mortality, while evidence-based medical therapies remain protective.

Cite This Study

Manfrini et al. (2014) conducted a cohort in Acute coronary syndrome (n=437). Female sex vs. Male sex was evaluated on In-hospital mortality. In octogenarians with acute coronary syndrome, in-hospital mortality was similar between women (21.1%) and men (21.0%), with hypotension, Killip class ≥2, and STEMI as independent predictors of death.

synapsesocial.com/papers/6aa026033ffc717e97be8a17https://doi.org/10.1093/eurheartj/sut019
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring In-hospital Death from Myocardial Infarction in Eastern Europe: From the International Registry of Acute Coronary Syndromes in Transitional Countries (ISACS-TC); on the Behalf of the Working Group on Coronary Pathophysiology & Microcirculation of the European Society of Cardiology2014 · 40 citations
  2. 2In-hospital case fatality rates for acute myocardial infarction in Romania2009 · 51 citations
  3. 3Factors influencing underutilization of evidence-based therapies in women2011 · 190 citations
  4. 4Perspectives: Rationale and design of the ISACS-TC (International Survey of Acute Coronary Syndromes in Transitional Countries) project2014 · 28 citations
  5. 5Third universal definition of myocardial infarction2012 · 3,090 citations