Key result
Age ≥75 in ACS is linked to ~112% higher in-hospital mortality risk versus age ≤74.
Why the study?
This study was conducted to describe differences in treatment and clinical outcomes between patients aged ≥75 years and those aged ≤74 years presenting with ACS and undergoing invasive management.
Does age ≥75 years compared to ≤74 years affect treatment patterns and mortality in patients with acute coronary syndrome undergoing invasive management?
Population
11 763 patients diagnosed with ACS undergoing coronary angiography
Comparison
Patients aged ≥75 years vs aged ≤74 years
Design
Prospective multicentre cohort study
Follow-up
Median 4.57 years
Authors
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Supports heightened in-hospital vigilance for ACS patients ≥75 years; leaves open age as independent 1-year mortality predictor.
Cohort (n=11,763)
Yes
Does age ≥75 years compared to ≤74 years affect treatment patterns and mortality in patients with acute coronary syndrome undergoing invasive management?
Effect estimate: aOR 2.12 (95% CI 1.62-2.78)
p-value: p=<0.001
Older patients (≥75 years) with ACS undergoing invasive management have higher in-hospital mortality and receive less secondary prevention, but age itself is not an independent predictor of long-term mortality.
Lawless et al. (2023) conducted a cohort in Acute coronary syndrome (ACS) (n=11,763). Age ≥75 years vs. Age ≤74 years was evaluated on In-hospital mortality (aOR 2.12, 95% CI 1.62-2.78, p=<0.001). Patients aged ≥75 years presenting with ACS had a significantly greater risk of in-hospital mortality compared to those aged ≤74 years (aOR 2.12; 95% CI 1.62-2.78; p<0.001).
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