What is the clinical evidence from this study?

Study design: Cohort. Population: Acute Coronary Syndrome (ACS) (n=551). Intervention: Advanced age (≥75 years) vs. Younger age (<75 years). Primary outcome: In-hospital death (p=0.315).

What question did this study set out to answer?

This study aims to assess risk factors and prognosis of acute coronary syndrome (ACS) in elderly patients compared to younger patients.

January 1, 2025World Journal of Cardiovascular DiseasesOpen Access

Acute Coronary Syndrome in the Elderly: Assessment of Risk Factors, Management Strategies and Complications

Q: What are the key findings of this study?

Advanced age (≥75 years) was not significantly associated with in-hospital mortality (0.0% vs 0.8%, p=0.315) in patients admitted for acute coronary syndrome, whereas severe coronary lesions and chronic kidney disease significantly increased the risk of death.

Q: What does this research mean for the field?

Advanced age (≥75 years) is not significantly associated with in-hospital mortality in patients admitted for acute coronary syndrome, whereas severe coronary lesions and chronic kidney disease significantly increase the risk of death. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

This study aims to assess risk factors and prognosis of acute coronary syndrome (ACS) in elderly patients compared to younger patients.

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Key result

Advanced age shows no link to in-hospital ACS mortality, unlike severe coronary lesions and CKD.

P=0.315
n=551

Why the study?

ACS is a leading cause of mortality worldwide, but it is unknown whether advanced age constitutes a prognostic factor.

Does advanced age (≥75 years) worsen the prognosis of ACS compared to younger age?

Population

551 ACS patients admitted to an intensive care unit at the South Francilian Hospital Center

Comparison

Older vs younger patients

Design

Retrospective analysis

Authors

GKGlodie Dimbu Kiadi AKAdolphe Mukombola Kasongo HEHervé Libérus Ayewanou Edorh

Discussion

Member takes

Overview

Advanced age should not yet alter ACS in-hospital risk stratification; leaves open lesion severity and CKD as primary drivers in prospective cohorts.

Key Points

This study aims to assess risk factors and prognosis of acute coronary syndrome (ACS) in elderly patients compared to younger patients.
Retrospective analysis of ACS patients admitted from January to December 2022 to the intensive care unit.
Total of 551 patient files analyzed, including 60 elderly patients (10.9%).
Demographics and cardiovascular risk factors were compared between age groups.
Elderly patients had higher rates of obesity (p = 0.007), smoking (p = 0.002), and dyslipidemia (p = 0.022).
Younger patients exhibited higher rates of hypertension (p < 0.001) and diabetes (p < 0.001).
Death was linked to severity of coronary lesions (p < 0.001) and chronic renal failure (p = 0.006), but age did not significantly affect mortality.

Study Design

Type

Cohort (n=551)

Multicenter

Structured PICO

Does advanced age (≥75 years) worsen the prognosis of ACS compared to younger age?

Population

551 patients admitted for acute coronary syndrome, including 60 elderly subjects aged 75 years or older, evaluated retrospectively for risk factors and in-hospital outcomes.

Exposure

Advanced age (≥75 years)

Comparator

Younger age (<75 years)

Outcome

Death at discharge (in-hospital mortality)hard clinical

Main Result

Absolute Event Rate: 0% vs 0.8%

p-value: p=0.315

In a retrospective cohort of ACS patients, in-hospital mortality was driven by coronary lesion severity and chronic kidney disease rather than advanced age per se.

Limitations

Monocentric retrospective nature with possible selection bias
Small number of elderly subjects with few complications recorded
No long-term follow-up
Unable to analyze the potential effect of comorbidities, frailty, organ dysfunction, and medication use
Small number of elderly subjects
Lack of long-term follow-up
Inability to analyze potential effect of comorbidities, frailty, and medication use

Cite This Study

Kiadi et al. (2025) conducted a cohort in Acute Coronary Syndrome (ACS) (n=551). Advanced age (≥75 years) vs. Younger age (<75 years) was evaluated on In-hospital death (p=0.315). Advanced age (≥75 years) was not significantly associated with in-hospital mortality (0.0% vs 0.8%, p=0.315) in patients admitted for acute coronary syndrome, whereas severe coronary lesions and chronic kidney disease significantly increased the risk of death.

synapsesocial.com/papers/6a2011a31517a826fb04eaf7 https://doi.org/10.4236/wjcd.2025.152007

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January 1, 2025World Journal of Cardiovascular DiseasesOpen Access

Acute Coronary Syndrome in the Elderly: Assessment of Risk Factors, Management Strategies and Complications

View Full Paper

Ask AI

Bookmark

Key result

Advanced age shows no link to in-hospital ACS mortality, unlike severe coronary lesions and CKD.

P=0.315
n=551

Why the study?

ACS is a leading cause of mortality worldwide, but it is unknown whether advanced age constitutes a prognostic factor.

Does advanced age (≥75 years) worsen the prognosis of ACS compared to younger age?

Population

551 ACS patients admitted to an intensive care unit at the South Francilian Hospital Center

Comparison

Older vs younger patients

Design

Retrospective analysis

Authors

GKGlodie Dimbu Kiadi AKAdolphe Mukombola Kasongo HEHervé Libérus Ayewanou Edorh

Discussion

Member takes

Overview

Advanced age should not yet alter ACS in-hospital risk stratification; leaves open lesion severity and CKD as primary drivers in prospective cohorts.

Key Points

This study aims to assess risk factors and prognosis of acute coronary syndrome (ACS) in elderly patients compared to younger patients.
Retrospective analysis of ACS patients admitted from January to December 2022 to the intensive care unit.
Total of 551 patient files analyzed, including 60 elderly patients (10.9%).
Demographics and cardiovascular risk factors were compared between age groups.
Elderly patients had higher rates of obesity (p = 0.007), smoking (p = 0.002), and dyslipidemia (p = 0.022).
Younger patients exhibited higher rates of hypertension (p < 0.001) and diabetes (p < 0.001).
Death was linked to severity of coronary lesions (p < 0.001) and chronic renal failure (p = 0.006), but age did not significantly affect mortality.

Study Design

Type

Cohort (n=551)

Multicenter

Structured PICO

Does advanced age (≥75 years) worsen the prognosis of ACS compared to younger age?

Population

551 patients admitted for acute coronary syndrome, including 60 elderly subjects aged 75 years or older, evaluated retrospectively for risk factors and in-hospital outcomes.

Exposure

Advanced age (≥75 years)

Comparator

Younger age (<75 years)

Outcome

Death at discharge (in-hospital mortality)hard clinical

Main Result

Absolute Event Rate: 0% vs 0.8%

p-value: p=0.315

In a retrospective cohort of ACS patients, in-hospital mortality was driven by coronary lesion severity and chronic kidney disease rather than advanced age per se.

Limitations

Monocentric retrospective nature with possible selection bias
Small number of elderly subjects with few complications recorded
No long-term follow-up
Unable to analyze the potential effect of comorbidities, frailty, organ dysfunction, and medication use
Small number of elderly subjects
Lack of long-term follow-up
Inability to analyze potential effect of comorbidities, frailty, and medication use

Cite This Study

synapsesocial.com/papers/6a2011a31517a826fb04eaf7 https://doi.org/10.4236/wjcd.2025.152007

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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