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Observational analysis demonstrated low probability of moderate/severe AG diagnosis in referrals, indicating significant cost savings through selective EGD use.
GP, EGD, and USS do not always provide uniform diagnoses; however, after a negative GP test, the probability of detecting moderate/severe AG using EGD is extremely low (3/447; 0.007%). In the first-line diagnosis of upper abdominal symptoms, substantial cost savings (90%) could be achieved by preserving EGD only for those (<10%) patients whose GP test indicates AG.
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P. Sipponen (2025) studied this question.
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