December 4, 2025PharmaceuticsOpen Access

Comparative Pharmacokinetics of Lutein and Zeaxanthin from Phospholipid, Liposomal, and MCT Formulations in SD Rats

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Discussion

Analysis reveals phosphatidylserine enhances lutein and zeaxanthin absorption in rats, suggesting potential ocular-health applications.

Phosphatidylserine formulation significantly improved plasma concentrations of lutein and zeaxanthin.
The mean C_max was highest at 69.63 ng/mL with phosphatidylserine versus 52.54 ng/mL for MCT oil.
Non-compartmental pharmacokinetic parameters were computed using a validated LC–MS/MS method across formulations.
Findings indicate phospholipid-based delivery systems could enhance bioavailability for ocular health.

Mehkri et al. (2025) studied this question.

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