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Pharmacokinetic Comparison of Lutein and Zeaxanthin in Granule, Beadlet, and Liposomal Powder Formulations Following Single Oral Administration in Male Sprague-Dawley Rats

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Study compares pharmacokinetics of lutein-zeaxanthin formulations in rats, indicating liposomal powder enhances absorption.

Liposomal powder formulations significantly enhance lutein absorption compared to granules and beadlets.
The study found Cmax of lutein was highest at 62.39 ng/mL in the liposomal powder formulation after administration.
Eighteen male Sprague-Dawley rats received different formulations, demonstrating robust pharmacokinetic analysis using LC-MS/MS.
These findings support the development of lipid-based formulations for improved bioavailability of retinal health nutrients.

Mehkri et al. (2025) studied this question.

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