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June 17, 2026NutrientsOpen Access

The Relative Bioavailability of Lutein and Zeaxanthin in the Presence of Omega-3 Supplements and Their Effect on Oxidative Stress Levels in Humans: A Pilot Study

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Authors

KKKingsley KaluTranslational Research Institute CMCharles W. McMonniesUNSW Sydney SLSophia LinUNSW Sydney

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Implication

Randomized trial evaluates the effect of omega-3 on lutein and zeaxanthin bioavailability and oxidative stress in adults, suggesting no significant benefits.

Key Points

This pilot study aims to assess the bioavailability of lutein and zeaxanthin in the presence of omega-3 fatty acids and their effect on oxidative stress levels.
Randomised, non-blinded, controlled study with 16 participants (10 men, 6 women)
Participants consumed L+Z supplements with or without omega-3 fatty acids for 12 days after a 7-day wash-out period
Serum levels of L+Z and oxidative stress were measured using Area Under the Curve (AUC) analysis.
Baseline serum L+Z concentrations were 2.23 µg/mL (control) and 1.20 µg/mL (intervention) at Day 7.
Post-wash-out, serum L+Z concentrations reached 2.98 µg/mL (control) and 3.02 µg/mL (intervention) by Day 19, with no significant difference in AUC measures (p > 0.05).
Incremental L+Z bioavailability was higher in the intervention group (4.36 µg/day/mL) compared to control (3.00 µg/day/mL), though not statistically significant (p > 0.05), and no significant effects on oxidative stress were observed (p > 0.05).

Cite This Study

Kalu et al. (2026) studied this question.

synapsesocial.com/papers/6a3238e2d50b63ecad2049e9 https://doi.org/10.3390/nu18121914

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Implication

Randomized trial evaluates the effect of omega-3 on lutein and zeaxanthin bioavailability and oxidative stress in adults, suggesting no significant benefits.

The Relative Bioavailability of Lutein and Zeaxanthin in the Presence of Omega-3 Supplements and Their Effect on Oxidative Stress Levels in Humans: A Pilot Study

Discussion

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Implication

Key Points

Cite This Study

The Relative Bioavailability of Lutein and Zeaxanthin in the Presence of Omega-3 Supplements and Their Effect on Oxidative Stress Levels in Humans: A Pilot Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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