Controlled Release of Ketoprofen via PLGA Nanoparticles: An In Vitro Study for Rheumatoid Arthritis Therapy

Q: What type of study is this?

This is a In Vitro Study study.

Soumen Samanta; Kazi Asraf Ali; Manas Bhowmik; Samir Das; Dipika Mandal

doi:10.1039/d5pm00196j

December 2, 2025RSC PharmaceuticsOpen Access

Controlled Release of Ketoprofen via PLGA Nanoparticles: An In Vitro Study for Rheumatoid Arthritis Therapy

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Key Points

Ketoprofen release from PLGA nanoparticles improves therapy for rheumatoid arthritis, addressing solubility challenges.
In vitro findings illustrate enhanced drug delivery effectiveness using biodegradable polymers for NSAID formulation.
Microparticle analysis demonstrated effective control over drug release rates from PLGA nanostructures for arthritis treatment.
Research highlights the advantages of biodegradable nanoparticles in improving the therapeutic outcomes of NSAIDs.

Implication

In vitro study shows NSAID-loaded PLGA nanoparticles enhance therapy for rheumatoid arthritis, suggesting better drug delivery.

Abstract

Ketoprofen (KN) is one of the most commonly used non-steroidal anti-inflammatory drugs (NSAID). Low aqueous solubility and adverse gastrointestinal effects following oral dosing are the main challenges. Biodegradable polymers like...

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Cite This Study

Samanta et al. (2025) studied this question.

synapsesocial.com/papers/6930e8cdea1aef094cca3706 https://doi.org/10.1039/d5pm00196j

View Full Paper

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Controlled Release of Ketoprofen via PLGA Nanoparticles: An In Vitro Study for Rheumatoid Arthritis Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Controlled Release of Ketoprofen via PLGA Nanoparticles: An In Vitro Study for Rheumatoid Arthritis Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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