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December 5, 2025ScientificaOpen Access

Anthelminthic Activity of Piper nigrum , Albizia ferruginea , and Guarea cedrata Against Caenorhabditis elegans and Heligmosomoides polygyrus : In Vitro and In Silico Molecular Docking Approach

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Authors

NNNoumedem Anangmo Christelle NadiaYCYamssi CedricDADjam Chefor Alain

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Overview

In vitro tests show piperine inhibited helminth motility in Caenorhabditis elegans, suggesting potential as a novel anthelmintic treatment.

Key Points

  • Aqueous extracts exhibited significant inhibition of helminth larvae movement, leading to important findings for treatment.
  • The most effective extract against Heligmosomoides polygyrus was Piper nigrum with an IC50 of 0.04 mg/mL.
  • Molecular docking studies utilizing Schrodinger Maestro provided insights into compound interactions with targets like succinate dehydrogenase.
  • Findings imply these herbal extracts may serve as effective traditional treatments against helminth infections.

Cite This Study

Nadia et al. (2025) studied this question.

synapsesocial.com/papers/693231288e51979591dce5dchttps://doi.org/10.1155/sci5/1600933
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