Enhancing the search for potentially useful plant extracts with anthelmintic activity by combining traditional ethnoveterinary knowledge with wild type and stress reporter Caenorhabditis elegans in vitro screening tools

Anderson Munengwa; E T Nyahangare; Prosper Jambwa; Alban Mugoti; Stephen Mandara; Melody Dzviti; Nation Chikumba; Lyndy J. McGaw

doi:10.1016/j.sajb.2026.05.025

May 28, 2026South African Journal of BotanyOpen Access

Enhancing the search for potentially useful plant extracts with anthelmintic activity by combining traditional ethnoveterinary knowledge with wild type and stress reporter Caenorhabditis elegans in vitro screening tools

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Key Points

This research aims to identify plant extracts with potential anthelmintic properties using C. elegans as a model organism.
Investigated in vitro anthelmintic activity of five plant species used in traditional goat healing.
Evaluated nematocidal effects against all life cycle stages of Caenorhabditis elegans.
Assessed stress pathways activated by Euclea divinorum extract.
All plant extracts demonstrated nematocidal activity on C. elegans.
Bark extracts of Euclea divinorum exhibited the highest anthelmintic potency.
Combined extracts significantly increased overall anthelmintic activity.

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Implication

Examines anthelmintic activity of plant extracts in C. elegans, suggesting enhanced efficacy of combined extracts.

Abstract

• In vitro anthelmintic activity of five plant species used in traditional goat healing investigated. • Extracts were nematocidal against all life cycle stages of Caenorhabditis elegans . • Bark extracts of Euclea divinorum had the most potent anthelmintic activity. • E. divinorum extract triggered expression of various stress pathways in the model nematode. • Combining plant extracts of diverse species dramatically increased anthelmintic activity.

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Cite This Study

Munengwa et al. (2026) studied this question.

synapsesocial.com/papers/6a1a7f760307b78509431b1a https://doi.org/10.1016/j.sajb.2026.05.025

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Enhancing the search for potentially useful plant extracts with anthelmintic activity by combining traditional ethnoveterinary knowledge with wild type and stress reporter Caenorhabditis elegans in vitro screening tools

Key Points

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Implication

Abstract

Discussion

Cite This Study

Enhancing the search for potentially useful plant extracts with anthelmintic activity by combining traditional ethnoveterinary knowledge with wild type and stress reporter Caenorhabditis elegans in vitro screening tools

Key Points

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Implication

Abstract

Discussion

Cite This Study

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