What type of study is this?

This is a Cross-Sectional Study study.

December 5, 2025PLoS ONEOpen Access

HLA-B*44 is associated with a more than twentyfold increase in cyclic citrullinated peptide antibody serum level in Croatian patients with seropositive rheumatoid arthritis

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Retrospective study finds HLA-B*44 correlates with increased anti-CCP levels in rheumatoid arthritis, suggesting need for earlier intervention.

HLA-B*44 is linked to a twenty-fold increase in anti-CCP levels in patients.
Demographic data and rheumatoid factor levels informed the findings, indicating strong associations.
Retrospective cross-sectional study analyzed seropositive rheumatoid arthritis patients for HLA associations.
These findings may highlight the importance of early therapy to manage extreme antibody increases.

Aljinović et al. (2025) studied this question.

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Retrospective study finds HLA-B*44 correlates with increased anti-CCP levels in rheumatoid arthritis, suggesting need for earlier intervention.