What type of study is this?

This is a Cross-Sectional Study study.

December 1, 2025PLoS ONEOpen Access

HLA-B*44 is associated with a more than twentyfold increase in cyclic citrullinated peptide antibody serum level in Croatian patients with seropositive rheumatoid arthritis

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Authors

JAJure Aljinović DKDarko Kero DŠDaniela Šošo

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Implication

Retrospective analysis shows HLA-B*44 associates with a twenty-fold increase in anti-CCP in Croatian patients with rheumatoid arthritis, indicating potential need for earlier therapy.

Key Points

HLA-B*44 is significantly associated with a 20-fold increase in anti-CCP serum levels in patients.
The prevalence of HLA-B*44 and HLA-A*03 correlates with higher anti-CCP levels in seropositive rheumatoid arthritis.
Retrospective cross-sectional analysis collected data on HLA alleles, anti-CCP, and rheumatoid factor levels.
Highlighting the potential for aggressive therapy to reduce extreme increases in antibody levels among high-risk patients.

Cite This Study

Aljinović et al. (2025) studied this question.

synapsesocial.com/papers/69402c4d2d562116f29029b1 https://doi.org/10.1371/journal.pone.0334551

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Implication

Retrospective analysis shows HLA-B*44 associates with a twenty-fold increase in anti-CCP in Croatian patients with rheumatoid arthritis, indicating potential need for earlier therapy.

HLA-B*44 is associated with a more than twentyfold increase in cyclic citrullinated peptide antibody serum level in Croatian patients with seropositive rheumatoid arthritis

Discussion

Member takes

Implication

Key Points

Cite This Study

HLA-B*44 is associated with a more than twentyfold increase in cyclic citrullinated peptide antibody serum level in Croatian patients with seropositive rheumatoid arthritis

Discussion

Member takes

Implication

Key Points

Cite This Study

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