December 6, 2025Communications BiologyOpen Access

Multi-modal label-free imaging of cellular metabolism and oxidative stress in 3D brain tissue models

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Analysis reveals oxidative stress and metabolic reprogramming in engineered brain tissue, suggesting insights into mitochondrial dysfunction.

Oxidative stress and metabolic reprogramming observed in engineered 3D brain tissue models, impacting neuronal function.
Intensity imaging over 11 weeks showed metabolic differences between astrocytes and neurons, with glial support emphasized.
Utilized two-photon fluorescence imaging to assess cellular metabolism and interactions among microglia and astrocytes.
Findings suggest the method may lay a foundation for studying metabolic dysfunction in brain disorders.

Zhang et al. (2025) studied this question.

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Analysis reveals oxidative stress and metabolic reprogramming in engineered brain tissue, suggesting insights into mitochondrial dysfunction.