Genome assembly demonstrates protein microalgae biofortification potential in Auxenochlorella pyrenoidosa, suggesting new avenues for sustainable nutrition.
The green algae Auxenochlorella pyrenoidosa is capable of synthesizing substantial amounts of protein, containing all essential and non-essential amino acids necessary for sustainable human nutrition. A. pyrenoidosa RLXCh3 is a novel germplasm isolated from soil, with 63.65% protein content. To achieve biofortification based on RLXCh3, PacBio II/IIe sequencing, alongside Hi-C sequencing and full-length transcriptome analysis, were performed to construct an improved chromosome-level haplotypic genome assembly consisting of 12 chromosomes and a genome size of 53.07 Mbp. Scaffold N50 (4.94 Mbp) and contig N50 (1.74 Mbp) were obtained, with a total of 12,091 protein-coding genes predicted. In summary, we acquired excellent A. pyrenoidosa isolates and reported the first chromosome-scale map of A. pyrenoidosa, providing a valuable resource for in-depth commercial protein bioproduction and nutrient biofortification.
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Guan et al. (2025) studied this question.
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