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December 8, 2025Journal of Nutrition and MetabolismOpen Access

Intestinal ZIP8 Regulates Tissue Manganese Distribution and Modifies Manganese Overload in ZIP14 Deficiency

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Authors

YWYuze WuNZNing-ning Zhao

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Overview

Analysis shows altered manganese distribution in double knockout mice, suggesting intestinal ZIP8 modifies manganese overload in ZIP14 deficiency.

Key Points

  • ZIP8 regulates manganese absorption and distribution, impacting levels in liver and brain.
  • Significant reductions in blood manganese were observed in female double knockout mice, while bone levels remained elevated.
  • Assessment using intestine-specific Zip8 knockout mice revealed a crucial role for intestinal ZIP8 in manganese homeostasis.
  • Findings point to ZIP8 as a potential modifier of manganese overload conditions, particularly in ZIP14 deficiency.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c3f1https://doi.org/10.1155/jnme/6717314
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced Mn uptake of pleiotropic ZIP8 SNP is caused by its loss of Mn-responsive accumulation on the cell-surface2024 · 1 citations
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  3. 3Expression of Manganese Transporters ZIP8, ZIP14, and ZnT10 in Brain Barrier Tissues2024 · 17 citations
  4. 4The Inherited Intestinal Microbiota from Myeloid-Specific ZIP8KO Mice Impairs Pulmonary Host Defense against Pneumococcal Pneumonia2023 · 3 citations
  5. 5Zip14 (Slc39a14) metal transporter dysfunction leads to <i>Akkermansia</i> dysbiosis and inflammation in intestinal epithelium via epigenetic changes2026