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June 8, 2026Gut MicrobesOpen Access

Zip14 (Slc39a14) metal transporter dysfunction leads to Akkermansia dysbiosis and inflammation in intestinal epithelium via epigenetic changes

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Authors

FJFelix R. JimenezValdosta State UniversityCRCourtney H. RuggieroUniversity of FloridaRCRobert J. CousinsUniversity of Florida

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Implication

Randomized trial demonstrates the role of Zip14 in controlling intestinal inflammation and microbial balance.

Key Points

  • This research aims to investigate the role of Zip14 in zinc transport and its impact on intestinal microbiota and inflammation.
  • Conducted experiments using global Zip14 deletion in mice.
  • Analyzed gene expression in enterocytes using RNA sequencing.
  • Utilized ATAC sequencing and ChIP assays to assess chromatin accessibility.
  • Zip14 KO mice showed increased Akkermansia levels and elevated inflammatory cytokines.
  • Significant up-regulation of mucin synthesis-related genes St6galnac1 and Muc2 was observed.
  • Oral supplementation of zinc or Akkermansia mitigated the dysbiosis and inflammation in KO mice.

Cite This Study

Jimenez et al. (2026) studied this question.

synapsesocial.com/papers/6a265cffad53cfb9357c638chttps://doi.org/10.1080/19490976.2026.2684080
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