December 8, 2025SchizophreniaOpen Access

Trajectory analysis of BMI increase induced by second-generation antipsychotics in first-episode schizophrenia: a secondary analysis based on CNFEST****

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Authors

XYXiaolin YinHarbin Medical University TZTianhang ZhouCentral University of Finance and Economics XGXiaodong GuoChinese Academy of Sciences

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Implication

Analysis reveals distinct BMI trajectories in first-episode schizophrenia patients treated with antipsychotics, suggesting dynamic risk stratification is needed.

Key Points

Distinct BMI trajectories identified in first-episode schizophrenia patients under antipsychotics, indicating varying weight gain patterns.
Subjects included 361 drug-naïve first-episode schizophrenia patients, with 7 BMI measurements over 12 months.
Secondary analysis employed latent class trajectory modeling to categorize weight gain patterns based on baseline characteristics.
Findings highlight the need for targeted interventions for patients at risk of early weight gain with specific medications.

Cite This Study

Yin et al. (2025) studied this question.

synapsesocial.com/papers/693624ba4fa91c937236c893 https://doi.org/10.1038/s41537-025-00710-1

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Implication

Analysis reveals distinct BMI trajectories in first-episode schizophrenia patients treated with antipsychotics, suggesting dynamic risk stratification is needed.

Trajectory analysis of BMI increase induced by second-generation antipsychotics in first-episode schizophrenia: a secondary analysis based on CNFEST****

Discussion

Member takes

Implication

Key Points

Cite This Study

Trajectory analysis of BMI increase induced by second-generation antipsychotics in first-episode schizophrenia: a secondary analysis based on CNFEST****

Discussion

Member takes

Implication

Key Points

Cite This Study

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