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December 4, 2025BMC PsychiatryOpen Access

Longitudinal effects of atypical antipsychotic drugs on body composition in first-episode and chronic schizophrenia patients

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Authors

YMYuhan MaTianjin University of Technology YLYou LiSouthwest University

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Implication

Observational analysis shows atypical antipsychotic drugs influence body composition in first-episode schizophrenia, highlighting metabolic stability in chronic cases.

Key Points

Body composition metrics increased significantly in first-episode schizophrenia patients treated with atypical antipsychotics.
Weight, body mass index, and waist circumference surged by 1.85 kg, 0.70 kg/m², and 3.07 cm every 4 weeks with olanzapine.
A linear mixed-effects model assessed changes across 70 inpatients over 12 weeks, focused on body fat distribution characteristics.
Findings suggest the early treatment phase is critical for monitoring metabolic changes and potentially preventing cardiometabolic risks.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/6930dc8aea1aef094cca28ca https://doi.org/10.1186/s12888-025-07540-6

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Implication

Observational analysis shows atypical antipsychotic drugs influence body composition in first-episode schizophrenia, highlighting metabolic stability in chronic cases.

Longitudinal effects of atypical antipsychotic drugs on body composition in first-episode and chronic schizophrenia patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Longitudinal effects of atypical antipsychotic drugs on body composition in first-episode and chronic schizophrenia patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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