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December 8, 2025Cardiovascular MedicineOpen Access

Mechanisms Involved in the Adverse Cardiovascular Effects of Selective Cyclooxygenase-2 Inhibitors

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Authors

ALAsela Berenice López-Cuellar

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Overview

Review uncovers cardiovascular complications related to selective cyclooxygenase-2 inhibitors, suggesting thrombosis may arise from altered macrophage function and prostaglandin levels.

Key Points

  • This review aims to identify the mechanisms by which selective cyclooxygenase-2 inhibitors contribute to cardiovascular complications.
  • Analysis of literature on selective cyclooxygenase-2 inhibitors and their cardiovascular effects
  • Examination of pathophysiological mechanisms involving thrombosis and macrophage activity
  • Evaluation of genetic factors impacting cardiovascular risk
  • Selective cyclooxygenase-2 inhibitors are linked to increased cardiovascular complications due to thrombosis
  • Altered macrophage function and altered prostaglandin levels contribute to the cardiovascular risks
  • Genetic polymorphisms and matrix metalloproteinases are implicated in the adverse effects of coxibs.

Cite This Study

Asela Berenice López-Cuellar (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cd94https://doi.org/10.3390/cardiovascmed28010005
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