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December 8, 2025Small StructuresOpen Access

Nanozyme‐Integrated 3D‐Printed Gradient Scaffold Rescues Redox Homeostasis for Enhanced Osteochondral Repair

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Authors

CHChuan HuJLJianyi LiGJGu Jin

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Overview

In vitro and in vivo assays improved redox homeostasis and biocompatibility in osteochondral repair, indicating a novel scaffold's potential.

Key Points

  • This research aims to develop a biomimetic scaffold to enhance osteochondral repair by maintaining redox homeostasis.
  • Fabrication of a 3D-printed gradient antioxidant scaffold functionalized with Prussian blue nanozymes.
  • Incorporation of osteogenic and antisenescence hydrogels into specific regions of the scaffold.
  • Evaluation of scaffold performance through in vitro and in vivo assays, focusing on biocompatibility and differentiation effects.
  • The scaffold effectively scavenged reactive oxygen species (ROS) and enhanced biocompatibility.
  • It maintained cellular homeostasis by upregulating GPX4 expression and inhibiting ferroptosis.
  • Promoted osteogenic differentiation and mineralization of rat bone marrow stem cells (rBMSCs) via the PI3K‐AKT signaling pathway.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236ce95https://doi.org/10.1002/sstr.202500413
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Also Consider

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  3. 3Relieving oxidative stress microenvironment and promoting vascularized bone formation to treat femoral head necrosis using 3D-printed scaffold with ultralong-term multienzyme-like activity2025 · 6 citations
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