Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 2025Journal of Orthopaedic TranslationOpen Access

Relieving oxidative stress microenvironment and promoting vascularized bone formation to treat femoral head necrosis using 3D-printed scaffold with ultralong-term multienzyme-like activity

View Full Paper
Ask AI
Bookmark
Share

Authors

XXXiaobo XieJZJinwei ZhangZWZhaoying Wu

Discussion

Loading...

Member takes

Overview

Preclinical study demonstrates that a 3D-printed antioxidant scaffold enhances vascularized bone regeneration in osteonecrosis models, highlighting its therapeutic potential for hip preservation.

Key Points

  • To develop and evaluate a 3D-printed nanoparticle-doped scaffold with multienzyme-like activity that relieves oxidative stress and promotes vascularized bone regeneration for osteonecrosis of the femoral head.
  • Synthesized nanoparticles via oxidation and 3D-printed nanoparticle-doped PLGA scaffolds using fused deposition modeling.
  • Evaluated in vitro antioxidant multienzyme-like activity over 30 days, osteogenesis, angiogenesis, and PI3K/AKT signaling pathway involvement.
  • Tested therapeutic outcomes in a clinically relevant rabbit model of osteonecrosis of the femoral head undergoing core decompression.
  • The scaffold maintained superoxide dismutase-like and catalase-like activities for over 30 days in vitro, catalyzing reactive oxygen species into oxygen and boosting cell viability via the PI3K/AKT pathway.
  • Nanoparticle-doped PLGA significantly enhanced both osteogenic and angiogenic performance compared to unmodified PLGA.
  • Combined core decompression and scaffold implantation reduced osteoblast necrosis and accelerated vascularized bone formation in rabbits.

Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/6a820b445feb15765cbf6f76https://doi.org/10.1016/j.jot.2025.06.010
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 13D‐Printed Porous Titanium Alloy Scaffolds Incorporated With Tetramethylpyrazine‐Loaded Composite Hydrogels Enhance Angiogenesis and Bone Repair for Femoral Head Osteonecrosis2026
  2. 2Oxygen-enhanced 3D-printed scaffolds for repair of ischemic bone2025
  3. 3A 3D-printed scaffold featuring oxygen generation and osteoimmunity regulation for challenging bone regeneration2026
  4. 4Nanozyme‐Integrated 3D‐Printed Gradient Scaffold Rescues Redox Homeostasis for Enhanced Osteochondral Repair2025 · 2 citations
  5. 53D-printed oxygen-releasing scaffolds promote bone repair via angiogenesis and osteogenesis2025