What question did this study set out to answer?

To evaluate the effect of pre-transplant anxiety and depression on the outcomes of AML patients after allogeneic transplantation.

December 8, 2025Blood

Impact of pre-transplant anxiety and depression on outcomes of AML patients after allogeneic transplantation

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Authors

NANeda AmirmokhtariThe University of Kansas Health System

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Implication

Retrospective analysis shows no significant impact of pre-transplant depression or anxiety on outcomes in AML patients post-Allo-SCT, suggesting potential benefits from psychology-oncology support.

Key Points

To evaluate the effect of pre-transplant anxiety and depression on the outcomes of AML patients after allogeneic transplantation.
115 adult AML patients post-Allo-SCT were reviewed from 2022 to 2024.
Depression and anxiety assessed using PHQ-9 and GAD-7 during pre-transplant evaluation.
Cognitive function assessed with Montreal Cognitive Assessment (MoCA).
Kaplan-Meier model used for survival analysis; log-rank test compared survival outcomes.
Estimated 3-year overall survival was 72%, and progression-free survival was 67%.
No significant associations found between depression, anxiety severity, and overall or progression-free survival.
An association between depression severity and incidence of any grade acute graft-versus-host disease (aGVHD) was noted.

Cite This Study

Neda Amirmokhtari (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cf87 https://doi.org/10.1182/blood-2025-2851

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Implication

Retrospective analysis shows no significant impact of pre-transplant depression or anxiety on outcomes in AML patients post-Allo-SCT, suggesting potential benefits from psychology-oncology support.

Impact of pre-transplant anxiety and depression on outcomes of AML patients after allogeneic transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of pre-transplant anxiety and depression on outcomes of AML patients after allogeneic transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

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