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December 8, 2025BloodOpen Access

Treatment outcomes in patients with newly diagnosed multiple myeloma receiving ixazomib as initial therapy: A retrospective, observational, real-world historical database analysis from China

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Authors

GAGang AnWYWenqiang YanSDShuhui Deng

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Overview

Retrospective analysis shows ixazomib improves progression-free survival in transplant-ineligible multiple myeloma patients, indicating it as a strong first-line treatment.

Key Points

  • This study evaluates the efficacy and safety of ixazomib-based regimens in treating newly diagnosed multiple myeloma patients.
  • Retrospective database analysis of patients in the NICHE-MM registry
  • Included transplant-ineligible patients aged 18 and older
  • Primary outcomes include overall survival, progression-free survival, and treatment patterns
  • Overall response rate of 82%, with 32% achieving complete response
  • Median progression-free survival of 24.2 months observed
  • Treatment-related adverse events were manageable

Cite This Study

An et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d0b8https://doi.org/10.1182/blood-2025-2246
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