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December 8, 2025BloodOpen Access

Single-cell analysis and functional profiling reveal galectin-3–driven reprogramming of the tumor immune microenvironment in transformed follicular lymphoma

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Authors

HZHuilai Zhang

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Overview

Single-cell analysis reveals galectin-3 enhances immune evasion via CD8+ T cell dysfunction in transformed follicular lymphoma, suggesting immunotherapy implications.

Key Points

  • This research aims to understand how galectin-3 reprograms the immune microenvironment in transformed follicular lymphoma.
  • Utilized single-cell RNA sequencing to analyze tumor immune microenvironment.
  • Validated findings with multiplex immunofluorescence staining and in vitro assays.
  • Conducted research using mouse xenograft models.
  • Transformed follicular lymphoma patients have increased exhausted CD8+ T cells with checkpoint receptor expression.
  • Galectin-3 was found to impair CD8+ T cell proliferation and cytotoxicity, causing exhaustion.
  • The galectin-3 inhibitor GB1107 improved T cell function and showed potential as an immunotherapy.

Cite This Study

Huilai Zhang (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d116https://doi.org/10.1182/blood-2025-5033
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