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December 8, 2025BloodOpen Access

Integrated single-cell and spatial analysis identifies T cell exhaustion and adhesion signatures in early follicular lymphoma transformation

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Authors

PAPaula Aguirre‐RuizNavarre Institute of Health ResearchAPAna Alfonso PiérolaHumanitas UniversityEPEsther PenaNavarre Institute of Health Research

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Overview

Integrated analysis reveals T cell exhaustion and adhesion signatures in early follicular lymphoma transformation, suggesting an immunosuppressive niche.

Key Points

  • This research aims to characterize transcriptional and spatial features associated with follicular lymphoma transformation.
  • Combined single-cell RNA sequencing and spatial transcriptomics on lymph node samples.
  • Analyzed five lymph node samples at diagnosis for DLBCL and FL cases.
  • Identified transcriptional signatures and assessed mutational landscape via scDNA-seq.
  • Found distinct T cell exhaustion and adhesion signatures in transformed follicular lymphoma.
  • Identified clonal hematopoiesis-related mutations in tumor microenvironment cells.
  • Revealed differences in the spatial architecture of malignant B cells across different lymphoma stages.

Cite This Study

Aguirre‐Ruiz et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e580https://doi.org/10.1182/blood-2025-3539
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrated Single-Cell and Spatial Multi-Omics of Clonal Precursors and Immune Niches in Germinal Center Lymphomas2026 · 1 citations
  2. 2Abstract 6198: Single cell spatial multi-omic characterization of the tumor microenvironment in transformed follicular lymphoma2026
  3. 3Abstract PR001: Cytokine-linked stromal remodeling in transformed follicular lymphoma impacts macrophage function and can be detected non-invasively2026
  4. 4Genetic and Transcriptomic Profiles Identify Potential Therapeutic Targets of Concurrent Follicular and Diffuse Large B‐Cell Lymphoma and Transformed Follicular Lymphoma2026 · 1 citations
  5. 5Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma2024 · 11 citations