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December 8, 2025BloodOpen Access

Longitudinal single-cell profiling of the bone marrow heterogeneity identifies the T-cell niche supporting cancer persister cells in follicular lymphoma

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Authors

GBGabriel BrisouInstitut Paoli-CalmettesCBCharles BrottierInsermBNBertrand NadelCentre National de la Recherche Scientifique

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Overview

Longitudinal analysis reveals alterations in the bone marrow T-cell landscape in follicular lymphoma, indicating a supportive niche for drug-resistant tumor cells.

Key Points

  • This research aims to characterize the bone marrow T-cell niche in follicular lymphoma and identify factors supporting cancer persister cells.
  • Analyzed bone marrow T-cell profiles in low tumor burden patients receiving Rituximab monotherapy.
  • Conducted single-cell profiling of paired bone marrow aspirates from patients at diagnosis and remission.
  • Characterized T-cell landscapes and compared them with healthy donors' samples.
  • Identified significant alterations in T-cell populations, including increased Treg and dysfunctional cytotoxic T cells.
  • Found that certain T-cell subsets were associated with poorer clinical outcomes.
  • Demonstrated that the bone marrow remains a supportive niche for residual tumor B cells even after therapy.

Cite This Study

Brisou et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc96https://doi.org/10.1182/blood-2025-553
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intratumoral B cell diversity in follicular lymphoma revealed by single-cell paired transcriptome and BCR sequencing2025
  2. 2Integrated single-cell and spatial analysis identifies T cell exhaustion and adhesion signatures in early follicular lymphoma transformation2025
  3. 3Spatially resolved profiling reveals the perifollicular border zone as a key immunologic hub in follicular lymphoma undergoing mosunetuzumab therapy2025
  4. 4Abstract A049: Spatially resolved microenvironment profiling reveals distinct follicular lymphoma archetypes2026
  5. 5Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target2024 · 20 citations