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December 8, 2025BloodOpen Access

Spatially resolved profiling reveals the perifollicular border zone as a key immunologic hub in follicular lymphoma undergoing mosunetuzumab therapy

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Authors

APAri PelcovitsDTDiana O. TreabaPDPatrycja M. Dubielecka

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Overview

Spatial analysis reveals peripheral zones as immunologic hubs driving T cell activation in follicular lymphoma, suggesting novel therapeutic combinations.

Key Points

  • This research investigates the role of the perifollicular border zone in T cell recruitment during mosunetuzumab therapy for follicular lymphoma.
  • Analyzed tumor microenvironment using spatially resolved transcriptomics and multiplex immunofluorescence.
  • Subjects receiving mosunetuzumab were analyzed post-treatment via biopsies to assess changes in immune cell dynamics.
  • Used differential gene expression and spatial deconvolution techniques to characterize TME composition.
  • Identified perifollicular border zone as key area for CD8+ T cell and dendritic cell interactions.
  • Noted upregulation of T cell activity markers and exhaustion signals in the tumor microenvironment.
  • Observed significant changes in cellular neighborhoods, indicating diversity and T cell recruitment dynamics.

Cite This Study

Pelcovits et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db19https://doi.org/10.1182/blood-2025-5327
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract A049: Spatially resolved microenvironment profiling reveals distinct follicular lymphoma archetypes2026
  2. 2Longitudinal single-cell profiling of the bone marrow heterogeneity identifies the T-cell niche supporting cancer persister cells in follicular lymphoma2025
  3. 3Abstract 6198: Single cell spatial multi-omic characterization of the tumor microenvironment in transformed follicular lymphoma2026
  4. 4Response-adapted treatment with mosunetuzumab with or without obinutuzumab and polatuzumab vedotin in treatment naïve follicular and marginal zone lymphoma: Final results and phased-seq MRD analysis2025 · 2 citations
  5. 5Spatial proteomics of the bone marrow reveals distinct Tumor–Immune niches in smoldering and relapsed myeloma and their remodeling in response to bispecific antibody and CAR-T therapy2025