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December 8, 2025BloodOpen Access

Cerebral hemodynamic response to chronic transfusion is associated with cerebral vasculopathy in sickle cell anemia

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Authors

TUTara M. UrnerGeorgia Institute of TechnologyJOJada OriahiGeorgia Institute of TechnologyKTKatherine TurrentineGeorgia Institute of Technology

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Implication

Analysis reveals endothelial dysfunction and cerebral vasculopathy are linked to transfusion response in sickle cell anemia patients.

Key Points

  • This analysis aims to explore the association between cerebral blood flow and vasculopathy in sickle cell anemia patients undergoing chronic transfusions.
  • Patients with HbSS on chronic transfusion were enrolled in an IRB-approved study.
  • Regional cerebral blood flow (CBF) was assessed using DCS before and after transfusion.
  • Vasculopathy was evaluated through MRI/MRA reports and categorized as present or absent.
  • Multivariate models were utilized to analyze the relationships among CBF, transfusion response, and vasculopathy.
  • 39% of patients showed evidence of vasculopathy at the time of transfusion.
  • Pre-transfusion CBF was significantly associated with vasculopathy presence and status at follow-up.
  • Lower pre-transfusion CBF correlated with higher vasculopathy incidence after transfusion.

Cite This Study

Urner et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1b9https://doi.org/10.1182/blood-2025-531
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Also Consider

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  1. 1Abstract A062: Assessment of predictive factors for infarct development in sickle cell disease2026 · 1 citations
  2. 2Abstract A097: Cerebral capillary blood transit time in sickle cell anemia2026
  3. 3Abstract DP271: Sex Differences Exist in Cerebrovascular Reactivity in Children2026 · 1 citations
  4. 4The enrichment of T-regulatory cells as a potential therapeutic approach for cerebral vasculopathy in sickle cell disease2025
  5. 5Altered cerebral blood flow and functional connectivity in sickle cell disease2025