What type of study is this?

This is a Human Clinical Trial study (also classified as: Pre-Registered Trial).

What question did this study set out to answer?

This research aims to explore tumor-intrinsic heterogeneity and the immune microenvironment in mantle-cell lymphoma.

December 8, 2025BloodOpen Access

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Randomized trial identifies biomarkers and tumor heterogeneity in mantle-cell lymphoma, suggesting implications for treatment.

This research aims to explore tumor-intrinsic heterogeneity and the immune microenvironment in mantle-cell lymphoma.
Conducted an open-label randomized multicenter trial.
Involved single-cell RNA sequencing of samples from 33 patients.
Utilized UMAP clustering to identify distinct cell populations.
Identified biomarkers associated with treatment resistance and tumor heterogeneity.
Demonstrated significant differences in immune cell profiles between classical, blastic, and pleomorphic MCL subtypes.
Revealed activation of specific signaling pathways in patients with poorer treatment responses.

Shen et al. (2025) studied this question.

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