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December 8, 2025BloodOpen Access

Evaluation of STAT6 and PD-L1 expression in Hodgkin/reed-sternberg (HRS)-like cells in Hodgkin lymphoma-like Richter transformation arising in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)

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Authors

YZYong ZhangYYin-HungGPGeraldine Pinkus

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Overview

Retrospective analysis assessed stat6 and pd-l1 expression in malignant cells during hodgkin transformation in cll patients, indicating potential for targeted therapies.

Key Points

  • To assess STAT6 and PD-L1 expression in Hodgkin lymphoma-like Richter transformation in CLL/SLL patients.
  • Conducted a retrospective analysis of 19 CLL/SLL cases with Richter transformation diagnosed from 2010 to 2025.
  • Evaluated histomorphology, immunophenotype, and EBV status through immunohistochemistry and in situ hybridization.
  • Classified cases into Type I and Type II based on histological characteristics and assessed treatment modalities.
  • All evaluable cases were negative for STAT6 expression; 76% demonstrated PD-L1 expression.
  • EBV positivity was found in 42% of cases, higher in Type II compared to Type I.
  • Median follow-up indicated 28% of patients died of disease within three years; 67% were alive.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d2e0https://doi.org/10.1182/blood-2025-5407
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Also Consider

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  1. 1Hodgkin Reed-Sternberg Cells of Classic Hodgkin Lymphoma: Morphology, Phenotype, Genotype, and Cell of Origin2026
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  3. 3Morphology guided spatial transcriptomics to study topography of Hodgkin reed sternberg cells interaction with tumor microenvironment and its impact in defining risk of progression in classical Hodgkin lymphoma.2025
  4. 4Assessment for acceleration and transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma using histologic and immunohistochemical features: a case series2024 · 3 citations
  5. 5Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma2024 · 13 citations