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December 8, 2025BloodOpen Access

Real world epidemiological trends in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), England 2014-2021: Preliminary data from the uncover Study group

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Authors

TAToyyib AbdulkareemHLHanhua LiuMBMark Bishton

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Overview

Epidemiology reveals increased blood cancer incidence and survival disparities in Hodgkin lymphoma, suggesting a need for tailored healthcare strategies.

Key Points

  • The study aims to assess the epidemiology and survival of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) in England from 2014 to 2021.
  • Data from the National Cancer Registration Dataset for patients diagnosed with blood cancer in England were analyzed.
  • Crude and age-standardized incidence rates along with incidence rate ratios were calculated using Poisson regression.
  • Overall survival was assessed using Kaplan–Meier and Cox regression analyses, adjusting for various patient characteristics.
  • 1648 patients with NLPHL were identified, showing a median diagnosis age of 49 years.
  • The overall relative survival at 5 years was found to be 91.6%, while overall survival was 90.7%.
  • Incidence rates of NLPHL varied significantly by gender, age, and deprivation level, highlighting geographical variations in Hodgkin lymphoma incidences.

Cite This Study

Abdulkareem et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d2fchttps://doi.org/10.1182/blood-2025-6298
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Also Consider

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  1. 1Early-stage nodular lymphocyte predominant Hodgkin lymphoma: Disease characteristics, treatment pattern, and long-term outcomes from a tertiary care cancer institute in India2025
  2. 2Academic cancer programs deliver improved long-term survival in nodular lymphocyte predominant Hodgkin lymphoma: Insights from 7,000+ United States patients2025
  3. 3Abstract 6468: Nodular lymphocyte predominant hodgkin lymphoma: A national cancer database analysis with focus on hispanics2024
  4. 4Trends and socio‐economic disparities in chronic lymphocytic leukaemia 2014–2022: An England‐wide cohort study from the <scp>UNCOVER</scp> group2026
  5. 5Outcomes of allogeneic hematopoietic stem cell transplantation in nodular lymphocyte-predominant Hodgkin lymphoma: A registry-based study from the EBMT-LWP2025