Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 19, 2026British Journal of HaematologyOpen Access

Trends and socio‐economic disparities in chronic lymphocytic leukaemia 2014–2022: An England‐wide cohort study from the UNCOVER group

View Full Paper
Ask AI
Bookmark
Share

Authors

TETemitope ErinfolamiUniversity of LiverpoolAFAmelia FisherUniversity of LeedsIKIndrani KarphaUniversity of Liverpool

Discussion

Loading...

Member takes

Overview

Cohort study demonstrates regional and socioeconomic disparities in survival among patients with chronic lymphocytic leukaemia, highlighting persistent inequities in cancer care.

Key Points

  • To evaluate chronic lymphocytic leukaemia (CLL) epidemiology, incidence trends, and socioeconomic survival disparities in the modern treatment era.
  • Extracted data on 34,427 consecutive patients diagnosed with CLL between 2014 and 2022 from the English National Cancer Registration Dataset.
  • Conducted multivariable analyses to assess incidence rate ratios (IRR), overall survival (OS), net survival, and cause-specific survival (CSS) over a median follow-up of 74.4 months.
  • Socioeconomic deprivation was independently associated with higher incidence (IRR 1.06, 95% CI 1.02–1.10) and worse survival, showing an OS hazard ratio (HR) of 1.42 (95% CI 1.34–1.50) and CSS HR of 1.28 (95% CI 1.16–1.41) for the most versus least deprived quintiles.
  • Overall 1-, 3-, and 5-year OS rates were 90%, 78%, and 67% (net survival: 94%, 87%, and 81%), while annual CLL incidence dropped significantly by 2022 compared to 2014 (IRR 0.70, 95% CI 0.67–0.73).
  • Geographic region independently influenced CSS, with HRs relative to London ranging from 0.84 (95% CI 0.74–0.96) to 1.12 (95% CI 0.99–1.27).

Cite This Study

Erinfolami et al. (2026) studied this question.

synapsesocial.com/papers/6a8563d703308d306e2d73b1https://doi.org/10.1111/bjh.70765
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Social determinants of health and long-term survival in chronic lymphocytic leukemia/small lymphocytic lymphoma: A population-based analysis of 118,667 patients2025
  2. 2Trends and disparities in mortality from chronic lymphocytic leukemia in the geriatric population in the United States from 1999 to 2020: A nationwide analysis2025
  3. 3Real world epidemiological trends in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), England 2014-2021: Preliminary data from the uncover Study group2025
  4. 4Trends and ARIMA-based forecast of sepsis-related mortality in chronic lymphocytic leukemia (CLL): A u.S. population-based analysis from 1999 to 20302025
  5. 5Chronic lymphocytic leukemia mortality among u.S adults aged ≥65: A 56-year trend analysis and demographic disparities2025