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December 8, 2025Blood

Trends and disparities in mortality from chronic lymphocytic leukemia in the geriatric population in the United States from 1999 to 2020: A nationwide analysis

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Authors

AKAllahdad KhanAAArfa AhmadAFAyesha Fatima

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Overview

Nationwide analysis shows declining chronic lymphocytic leukemia mortality in the geriatric population, highlighting persistent disparities.

Key Points

  • Examine long-term mortality trends and disparities in chronic lymphocytic leukemia among older adults in the US.
  • Population-based analysis using CDC WONDER database
  • Identified CLL-related deaths among individuals aged ≥65 from 1999 to 2020
  • Calculated age-adjusted and crude mortality rates
  • Utilized Joinpoint regression for temporal trend analysis
  • 85,371 CLL-related deaths reported from 1999 to 2020
  • AAMR decreased from 11.18 to 7.75 per 100,000
  • Men had higher mortality rates than women, with a more significant decline in women
  • Midwest recorded highest AAMR; West reported lowest
  • Steepest declines seen in the 65–74 age group

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc3chttps://doi.org/10.1182/blood-2025-8016
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Also Consider

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  1. 1Chronic lymphocytic leukemia mortality among u.S adults aged ≥65: A 56-year trend analysis and demographic disparities2025
  2. 2Trends in chronic lymphocytic leukemia mortality among older adults with renal failure in the United States: A 25-year retrospective study.2025
  3. 3Trends and disparities in cerebrovascular disease–related mortality in patients with chronic lymphocytic leukemia: A retrospective analysis across two decades.2026
  4. 4Trends in chronic lymphocytic leukemia mortality among patients with pneumonia in the United States (1999–2024): A CDC wonder database analysis2025
  5. 5Trends and ARIMA-based forecast of sepsis-related mortality in chronic lymphocytic leukemia (CLL): A u.S. population-based analysis from 1999 to 20302025