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December 8, 2025BloodOpen Access

Trends in chronic lymphocytic leukemia mortality among older adults with renal failure in the United States: A 25-year retrospective study.

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Authors

SHSyed Belal HassanAAAnam AshfaqueMSMoazzam Shahzad

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Overview

Retrospective analysis reveals rising mortality trends in older adults with CLL and renal failure, indicating disparities by geography and sex.

Key Points

  • This study assesses trends in mortality among older adults with chronic lymphocytic leukemia and renal failure.
  • Analyzed CDC WONDER Multiple Cause of Death database from 1999–2024.
  • Identified deaths of adults aged ≥65 years with CLL and renal failure as contributing cause.
  • Calculated age-adjusted mortality rates (AAMRs) per 100,000 U.S. population.
  • Applied Joinpoint regression to evaluate temporal trends.
  • Total of 8,213 deaths recorded among older adults with CLL and renal failure.
  • AAMR increased from 0.6 in 1999 to 0.7 in 2024 with notable increases from 1999 to 2004 (+6.76% APC) followed by a decline (-0.21% APC).
  • Males had an AAMR of 1.2, three times higher than females (0.4).
  • Non-Hispanic Whites displayed the highest mortality rate (0.8).
  • AAMRs were higher in non-metropolitan areas (0.8) and the Midwest region (0.8), highlighting regional disparities.

Cite This Study

Hassan et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4f7https://doi.org/10.1182/blood-2025-8059
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Also Consider

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  1. 1Trends and disparities in mortality from chronic lymphocytic leukemia in the geriatric population in the United States from 1999 to 2020: A nationwide analysis2025
  2. 2Chronic lymphocytic leukemia mortality among u.S adults aged ≥65: A 56-year trend analysis and demographic disparities2025
  3. 3Trends in chronic lymphocytic leukemia mortality among patients with pneumonia in the United States (1999–2024): A CDC wonder database analysis2025
  4. 4Trends and disparities in cerebrovascular disease–related mortality in patients with chronic lymphocytic leukemia: A retrospective analysis across two decades.2026
  5. 5Trends and ARIMA-based forecast of sepsis-related mortality in chronic lymphocytic leukemia (CLL): A u.S. population-based analysis from 1999 to 20302025