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December 8, 2025Blood

Trends in chronic lymphocytic leukemia mortality among patients with pneumonia in the United States (1999–2024): A CDC wonder database analysis

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Authors

SHSyed Tawassul HassanSSShruthi SridharBTBishal Tiwari

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Overview

Analysis reveals significant reduction in mortality from CLL and pneumonia in older adults, indicating need for targeted public health efforts.

Key Points

  • This research aims to assess national mortality trends in chronic lymphocytic leukemia among older adults with pneumonia.
  • Analyzed death certificate data from the CDC WONDER database from 1999 to 2024.
  • Focused on adults aged ≥65 years with CLL as the underlying cause and pneumonia as a contributing cause.
  • Calculated Age-Adjusted Mortality Rates (AAMRs) per 100,000 population using Joinpoint regression.
  • A total of 13,951 deaths recorded with CLL as primary and pneumonia as a contributing cause.
  • AAMRs decreased by 68%, from 21.0 in 1999 to 6.7 in 2024.
  • Males had over twice the AAMR compared to females and non-Hispanic Whites had the highest AAMRs.

Cite This Study

Hassan et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2fehttps://doi.org/10.1182/blood-2025-8042
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mortality trends of chronic lymphocytic leukemia and pneumonia in the United States (1999–2023): A CDC-wonder analysis2025
  2. 2Trends and disparities in mortality from chronic lymphocytic leukemia in the geriatric population in the United States from 1999 to 2020: A nationwide analysis2025
  3. 3Chronic lymphocytic leukemia mortality among u.S adults aged ≥65: A 56-year trend analysis and demographic disparities2025
  4. 4Uneven gains: Disparities in pneumonia-associated mortality among myeloid leukemia patients in the United States, 1999–2020 — a CDC wonder and joinpoint analysis2025
  5. 5Trends in chronic lymphocytic leukemia mortality among older adults with renal failure in the United States: A 25-year retrospective study.2025