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December 8, 2025Blood

Effect of GVHD prophylaxis on renal function and survival outcomes in allogeneic hematopoietic cell transplant patients with pre-existing renal impairment

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Authors

MVMariola Vazquez‐MartinezTCTeresa CapriceJKJongphil Kim

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Overview

Retrospective analysis reveals acute kidney injury risk in renal impaired transplant patients, suggesting nephrotoxic regimens need reconsideration.

Key Points

  • Examine the effects of different GVHD prophylaxis regimens on renal outcomes and survival rates in hematopoietic cell transplant patients with existing renal impairment.
  • Single-center retrospective study of patients undergoing hematopoietic cell transplant with pre-existing renal impairment.
  • Comparison of GVHD prophylaxis regimens: post-transplant cyclophosphamide with sirolimus, tacrolimus, or methotrexate.
  • Assessment of acute kidney injury, non-relapse mortality, progression-free survival, and overall survival over 1 year post-transplant.
  • Acute kidney injury occurred in 47% of patients, varying by GVHD prophylaxis regimen used.
  • 1-year overall survival was 74%, influenced by age over 60 and HCT-CI scores greater than 3.
  • Pre-existing renal impairment significantly affected outcomes, particularly with eGFR <60.

Cite This Study

Vazquez‐Martinez et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d415https://doi.org/10.1182/blood-2025-7764
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Post-transplant cyclophosphamide-based graft-verses-host disease (GVHD) prophylaxis is associated with a low incidence of fibrotic chronic GVHD after allogeneic hematopoietic cell transplantation across diverse donor types2025
  2. 2Phase II Study of post transplant cyclophosphamide-based graft versus host disease prophylaxis after HLA-mismatched unrelated donor transplantation and reduced intensity conditioning: Results from the NMDP-sponsored access expansion Study2025
  3. 3Impact of conditioning intensity on outcomes after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025
  4. 4Impact of graft versus host disease prophylaxis with post transplant cyclophosphamide on the prognostic value of HCT-CI2025
  5. 5Severity and organ distribution of graft‐versus‐host disease with post‐transplant cyclophosphamide versus calcineurin inhibitor plus methotrexate/mycophenolate mofetil or sirolimus in allogenic HLA‐matched or single‐allele mismatched stem cell transplantation2024 · 5 citations