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December 8, 2025Blood

The role of pre-existing iron deficiency anemia in hospitalizations for cardiogenic shock

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Authors

AAAbdulmalek Aljafari

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Overview

Retrospective analysis shows that iron deficiency anemia reduces in-hospital mortality in cardiogenic shock patients, suggesting a protective role.

Key Points

  • This study aims to evaluate the impact of pre-existing iron deficiency anemia on hospital outcomes in patients admitted for cardiogenic shock.
  • Weighted retrospective analysis using the National Inpatient Sample (2016–2022)
  • Identified adult hospitalizations with primary diagnosis of cardiogenic shock
  • Stratification based on documented history of iron deficiency anemia
  • Comparative analysis of demographics and outcomes using multivariable logistic regression models
  • History of iron deficiency anemia associated with 65% lower in-hospital mortality (adjusted OR 0.35; p < 0.001)
  • Higher odds of PRBC transfusion (OR 2.54; p < 0.001)
  • Longer hospital stay (adjusted increase of 1.85 days; p = 0.043)
  • No significant differences in major complications by IDA status

Cite This Study

Abdulmalek Aljafari (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d422https://doi.org/10.1182/blood-2025-7911
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Also Consider

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  1. 1Impact of Anaemia and Iron Deficiency on Outcomes in Cardiogenic Shock Complicating Acute Myocardial Infarction2023 · 12 citations
  2. 2A58-07 Prevalence and Impact of Iron Deficiency Anemia in Hospitalized Patients With Acute Myocardial Infarction: A National Inpatient Sample Analysis, 2018-20202026
  3. 3Iron deficiency in acute coronary syndromes: prevalence and prognostic impact2025 · 1 citations
  4. 4Iron Deficiency and Outcomes in Hospitalized Heart Failure Patients2026
  5. 5Prevalence and outcomes of iron deficiency based on transferrin saturation in patients with acute heart failure2025