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December 12, 2023European Journal of Heart FailureOpen Access

Impact of Anaemia and Iron Deficiency on Outcomes in Cardiogenic Shock Complicating Acute Myocardial Infarction

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Why the study?

Data concerning the impact of anaemia and iron deficiency on clinical outcomes in patients with cardiogenic shock were scarce.

Does the presence of anaemia or iron deficiency impact clinical outcomes in patients with cardiogenic shock complicating acute myocardial infarction?

Population

427 CS patients due to AMI from the CULPRIT-SHOCK trial

Comparison

Neither anaemia nor ID vs anaemia without ID vs anaemia with ID vs ID without anaemia

Design

Substudy of the CULPRIT-SHOCK trial

Follow-up

30 days

Authors

DODanilo ObradovićGLGoran LoncarUZUwe Zeymer

Discussion

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Member takes

Overview

Anaemia without ID signals higher risk in AMI-CS; leaves open whether correction improves outcomes.

Structured PICO

Does the presence of anaemia or iron deficiency impact clinical outcomes in patients with cardiogenic shock complicating acute myocardial infarction?

P
Population
427 patients with cardiogenic shock (CS) complicating acute myocardial infarction (AMI) from the CULPRIT-SHOCK trial.
I
Intervention
Presence of anaemia (haemoglobin <13 g/dl in men and <12 g/dl in women) with or without iron deficiency (ID) (ferritin <100 ng/ml or transferrin saturation <20%).
C
Comparator
Patients having neither anaemia nor iron deficiency.
O
Outcome
Composite of all-cause death or renal replacement therapy at 30-day follow-up.composite

In patients with cardiogenic shock complicating AMI, anaemia without iron deficiency at presentation is associated with a significantly higher risk of 30-day mortality or need for renal replacement therapy, whereas iron deficiency alone does not impact these outcomes.

Cite This Study

Obradović et al. (2023) studied this question.

synapsesocial.com/papers/6a7cf84674bc62f97e6f74e9https://doi.org/10.1002/ejhf.3099
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of pre-existing iron deficiency anemia in hospitalizations for cardiogenic shock2025
  2. 2Iron deficiency in acute coronary syndromes: prevalence and prognostic impact2025 · 1 citations
  3. 3Iron Deficiency in Acute Coronary Syndrome Treated with Percutaneous Angioplasty—A Factor of Unestablished Significance2026
  4. 4The Additive Burden of Iron Deficiency in the Cardiorenal–Anaemia Axis: Scope of a Problem and its Consequences2014 · 74 citations
  5. 5Prevalence and outcomes of iron deficiency based on transferrin saturation in patients with acute heart failure2025