What question did this study set out to answer?

To analyze outcomes of de novo secondary CNS lymphoma based on anatomical compartment involvement.

December 8, 2025BloodOpen Access

Anatomical localization-based analysis of de novo secondary cns lymphoma

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Retrospective review identifies outcomes in CNS lymphoma, revealing implications for autologous stem cell transplant.

To analyze outcomes of de novo secondary CNS lymphoma based on anatomical compartment involvement.
Retrospective review of 34 patients diagnosed with de novo SCNSL at Mayo Clinic.
Patients categorized by primary site of CNS involvement: leptomeningeal vs parenchymal.
Estimated overall survival and progression-free survival using Kaplan-Meier method.
The complete response rate was 58.8%, with 61.8% receiving intrathecal chemotherapy.
Two-year overall survival rates were 75.0% for parenchymal versus 45.1% for leptomeningeal.
No significant associations found between survival outcomes and patient characteristics or anatomical involvement.

Wang et al. (2025) studied this question.

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