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December 8, 2025BloodOpen Access

Epidemiological survey of familial myelodysplastic syndromes/acute myeloid leukemia in Hawaii

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Authors

MTManasawee TanariyakulAMAkihiro MiyashitaDCDominic C. Chow

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Overview

Retrospective study reveals DNMT3A mutations impact survival in familial myelodysplastic syndromes and AML cases.

Key Points

  • The study aims to evaluate the epidemiology and clinical characteristics of familial myelodysplastic syndromes and acute myeloid leukemia in Hawaii.
  • Conducted a retrospective study at Queen's Medical Center
  • Gathered data from electronic medical records
  • Utilized next-generation sequencing for genetic analysis
  • Defined familial MDS/AML based on family history
  • 12 cases of familial MDS/AML among 1,686 patients identified
  • Median overall survival for familial MDS was 12.7 years
  • DNMT3A mutations detected in familial MDS patients
  • No NHOPI patients found in familial cases

Cite This Study

Tanariyakul et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d530https://doi.org/10.1182/blood-2025-7396
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic landscape of pediatric myelodysplastic syndrome in Japan2025
  2. 2An analysis of the mutational landscape of Acute Myeloid Leukemia at an urban tertiary care center: A retrospective cohort study2025
  3. 3B-214 Mutational Landscapes of Acute Myeloid Leukemia and Myelodysplastic Syndromes: A Database-Driven Comprehensive Myeloid Panel Analysis of DNA Variants and Gene Fusions2024
  4. 4Low utilization of cancer genetics referrals in newly diagnosed Acute Myeloid Leukemia2025
  5. 5MDS/AML and AML with myelodysplasia-related gene mutations: clinical and molecular similarities.2026