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December 8, 2025Blood

Racial and ethnic disparities in u.S. chronic lymphocytic leukemia clinical trial enrollment: A participation-to-prevalence analysis

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Authors

GMGabriel N. MannisMLMichaela LiedtkeJGJason Gotlib

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Overview

Retrospective analysis reveals racial and ethnic disparities in CLL clinical trial enrollment, suggesting targeted recruitment is needed.

Key Points

  • To assess racial and ethnic disparities in CLL clinical trial enrollment using participation-to-prevalence ratios (PPRs).
  • Conducted retrospective analysis of 42 interventional clinical trials for CLL in the U.S.
  • Aggregated baseline demographic data including race, sex, and age.
  • Calculated PPRs for racial groups based on SEER prevalence data.
  • Identified significant underrepresentation of Black and Hispanic patients in CLL trials.
  • PPRs were 0.86 for White, 0.65 for Black, and 0.92 for Asian participants.
  • Approximately 62% of trial participants were male.

Cite This Study

Mannis et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d542https://doi.org/10.1182/blood-2025-6308
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