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December 8, 2025Blood

Racial and socioeconomic disparities in clinical trial participation and outcomes in systemic peripheral T-cell lymphoma (PTCL): A multicenter retrospective Study

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Authors

KSKimberly SeymourNLNicholas LiMRMiguel Ruiz

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Overview

Retrospective study reveals racial and socioeconomic disparities in clinical trial enrollment and outcomes for systemic PTCL patients, indicating a need for equitable access.

Key Points

  • This study investigates disparities in clinical trial participation and outcomes based on race and socioeconomic status in systemic peripheral T-cell lymphoma.
  • Conducted a multicenter retrospective study across 10 academic centers in the U.S.
  • Analyzed data from 621 patients diagnosed with systemic peripheral T-cell lymphoma from 2010-2022.
  • Measured socioeconomic status using census data to create income quintiles and Social Deprivation Index figures.
  • Survival differences assessed using log-rank tests and Cox proportional hazards analysis.
  • Found significant racial disparities in clinical trial participation, with 7.1% of non-Hispanic Black patients enrolled versus 16% of non-Hispanic White patients.
  • Multivariable analysis showed non-Hispanic Black patients were less likely to enroll in trials (OR 0.32, p=.01).
  • Noted that lower socioeconomic status correlated with worse overall survival, highlighting the impact of access to care.

Cite This Study

Seymour et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d517https://doi.org/10.1182/blood-2025-4523
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