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December 8, 2025Blood

The role of hematopoietic stem cell transplantation in peripheral T-cell lymphoma not otherwise specified

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Authors

MMMuhamad Alhaj Moustafa

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Implication

Analysis reveals hematopoietic stem cell transplantation improves survival in PTCL-NOS patients, indicating disparities in treatment access by education and insurance.

Key Points

  • To analyze the impact of hematopoietic stem cell transplantation on survival in patients with PTCL-NOS.
  • Utilized the National Cancer Database to study patients aged 18+ with PTCL-NOS from 2004-2019.
  • Excluded patients lost to follow-up.
  • Evaluated overall survival using Kaplan-Meier and multivariate Cox regression analysis.
  • Overall survival was significantly improved in patients receiving HSCT (mOS 110.9 months) compared to those who did not (mOS 11.1 months).
  • HSCT rates increased over time, with significant variations by race/ethnicity and socioeconomic factors.
  • Advanced-stage patients had lower median overall survival (mOS 10.5 months), highlighting treatment disparities.

Cite This Study

Muhamad Alhaj Moustafa (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d743https://doi.org/10.1182/blood-2025-7150
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hematopoietic stem cell transplantation in T-cell lymphomas: A promising strategy challenging poor prognosis2025
  2. 2The Role of Stem Cell Transplantation In Hepatosplenic T-cell Lymphoma and Its Associated Survival Determinants: Analysis of an Updated Real-World Database2026
  3. 3Allogeneic stem cell transplantation for major T-cell lymphoma entities: an analysis of the EBMT-lymphoma working party2026 · 6 citations
  4. 4Comparable outcomes after autologous hematopoietic cell transplantation in T-cell lymphoma regardless of pre-transplant response: A key finding in resource-limited countries.2025
  5. 5Application of Autologous Hematopoietic Stem Cell Transplantation in the Treatment of Peripheral T-cell Lymphoma2024