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December 8, 2025Blood

Hematopoietic stem cell transplantation in T-cell lymphomas: A promising strategy challenging poor prognosis

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Authors

ALAmaya Llorente‐ChávezRFRodrigo Figueroa-MéndezITIldefonso Téllez

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Overview

Retrospective analysis shows HSCT enhances progression-free survival in T-cell lymphomas, indicating a viable option for poor prognosis cases.

Key Points

  • To evaluate the effectiveness of hematopoietic stem cell transplantation in T-cell lymphomas and its impact on patient outcomes.
  • Retrospective analysis of patients with T-cell lymphomas who underwent HSCT at a national referral center in Mexico from 2008 to 2024.
  • Descriptive statistics and survival analysis used Kaplan-Meier curves and log-rank tests.
  • Population included 40 patients with various T-cell lymphoma subtypes.
  • Median overall survival was 60 months, with significant variation among subtypes.
  • Progression-free survival was 28 months; higher risks of progression noted in relapsed/refractory cases.
  • HSCT successfully performed as consolidation therapy and showed improved outcomes, especially in advanced-stage disease.

Cite This Study

Llorente‐Chávez et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d73fhttps://doi.org/10.1182/blood-2025-7151
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparable outcomes after autologous hematopoietic cell transplantation in T-cell lymphoma regardless of pre-transplant response: A key finding in resource-limited countries.2025
  2. 2The role of hematopoietic stem cell transplantation in peripheral T-cell lymphoma not otherwise specified2025
  3. 3Allogeneic hematopoietic cell transplantation for T-cell/histiocyte-rich large B-cell lymphoma: An EBMT lymphoma working party study2026
  4. 4Peripheral T-cell lymphomas: Real-world insights into clinical features and prognosis2025 · 1 citations
  5. 5Long‐term outcomes after allogeneic versus autologous haematopoietic stem cell transplantation for T‐lymphoblastic lymphoma2026