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December 8, 2025BloodOpen Access

Sickle cell disease in the global south: Mapping the unmet burden using global burden of disease DALY estimates and its relevance to United States hematologists

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Authors

SYSaima YounasSGShakirat Gold‐OlufadiKKKushal Kriplani

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Overview

Analysis reveals significant mortality from sickle cell disease in sub-Saharan Africa, suggesting urgent health equity interventions are needed for U.S. hematologists.

Key Points

  • Quantify the regional and age-specific burden of sickle cell disease using disability-adjusted life years.
  • Extracted SCD-specific DALY, YLD, and YLL estimates from the Global Burden of Disease 2021 study.
  • Stratified data by region, age, sex, and Sociodemographic Index.
  • Analyzed temporal trends from 2000 to 2021 and projected trends through 2030.
  • Global SCD prevalence increased by 41% from 2000 to 2021.
  • Sub-Saharan Africa accounted for 75 to 80% of global DALYs and SCD-related deaths.
  • Higher DALY-per-birth ratio in the U.S. reflects chronic morbidity among aging survivors.

Cite This Study

Younas et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d581https://doi.org/10.1182/blood-2025-2601
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Burden and trends of sickle cell disease in the United States: Insights from the global burden of disease study 20212025
  2. 2Sickle cell disease: a comparative perspective on global and national initiatives2024 · 24 citations
  3. 3Global burden disparities and unmet needs of stroke in sickle cell disease2026
  4. 4Contemporary global burden of sickle cell anaemia under‐5 and under‐20: A systematic review and meta‐analysis2026
  5. 5Trends in the burden of sickle cell disorders in Sierra Leone, 1990–2023: An analysis of Global Burden of Disease Study 2023 estimates2026